Abstract
Rheumatoid arthritis is a chronic inflammatory illness that impacts the body joints. This causes in harmful joints, stiffness and swelling in the body joints. RA generally offence the joints of the body, commonly a lot of joints at once. RA usually impacts joints in the hand, wrist, and knee. In a joint infected with RA, the padding of the joint is going to be inflamed, makes a joint tissue harm and damage. This tissue harm can make a long-lasting or chronic pain, loss of balance, and misshapenness. The work designed to determinate the levels of anthropometric variables (age and BMI) immunological parameters (IL-27 and IL-35) and electrolyte (sodium, potassium and calcium) parameters in sera of rheumatoid arthritis female. The study contains 60 subjects who splitted in to two groups, the two groups is are healthy control group and rheumatoid arthritis patients group. There is non-significant (p>0.05) difference among control and patients in age and BMI, A very high significant elevation (P<0.001) has observed in the level of IL-27, IL-35 and sodium and a very high significant increase (P<0.001) has observed in the level of calcium in RA females compared with control, from another way, there is no significant (p> 0.05) difference in the study of potassium and Uric acid between healthy control and RA patients. The net result shows that there is a related relationship between the inflammatory immunological parameters (IL-27 and IL-35) with the infection by RA, and shows a big role for immunity system of the body to fight this disease, and yet shows that this disease effect on the ratio of electrolyte (Ca and Na) in the body of patients
Keywords: RA, Rheumatoid arthritis, inflammatory disease , IL-27, IL35, electrolyte and chronic disease
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