EXPRESSION OF EBV LATENT MEMBRANE PROTEIN 1 (LMP1) IN IRAQI WOMEN WITH CERVICAL CARCINOMA

EXPRESSION OF EBV LATENT MEMBRANE PROTEIN 1 (LMP1) IN IRAQI
WOMEN WITH CERVICAL CARCINOMA

Basim M. Khashman1*, Farah A. J. Al-Zahawi2, Thuraya K. Alwandawi3 and Muna J. Ali4
1,2,4National Cancer Research Center, University of Baghdad, Iraq.
3College of Dentistry, Aliraqia University, Iraq.
*e-mail : [email protected]

 

ABSTRACT : The design of this paper is to find the possible correlation of Epstein Barr virus infection ina group of Iraqi
women with cervical carcinoma though detection of Latent Membrane Protein 1 (LMP1) in these cervical tissues. Paraffinized
blocks of two groups were included. The first sample of 30 cervical carcinomatous tissues and 15 biopsies from an apparently
normal cervical tissues. All the samples were sectioned on a positive charged slides with 4 mm – thickness then submitted for
immunohistochemical (IHC) staining to detect viral LMP1 expression. Sixty three percentage (19 out of 30) of the studies group
showed positive overexpression as shown in with a significant association of the expression with cervical cancer with a significant
association (p = 0). The infection with EBV may be a possible causative agent affected the development of cervical cancer.
Further studies with large samples are recommended.