THE ONCOGENIC EFFECT OF EBV/HPV CO-INFECTION IN A GROUP OF IRAQI WOMEN WITH CERVICAL CARCINOMA

THE ONCOGENIC EFFECT OF EBV/HPV CO-INFECTION IN A GROUP OF
IRAQI WOMEN WITH CERVICAL CARCINOMA

Basim M. Khashman1*, Suhad K. Karim2 and Ghada Nazar Al-Jussani3
1National Cancer Research Center, University of Baghdad, Iraq.
2Department of Scientific Affairs, Presidency of the University of Baghdad, University of Baghdad, Iraq.
3Faculty of Medicine, Hashemite University, Jordan.
*e-mail: [email protected]

 

ABSTRACT : The current paper was designed to find the possible synergic effect of EBV infection with the HPV-16 in Iraqi
women suffering from cervical carcinoma. This retrospective study involved paraffinized blocks of two groups. The research
included 30 carcinomatous cervical tissues and 15 samples from normal cervical biopsies. After sectioning using positively
charged slides, immunohistochemistry (IHC) was performed to detect anti-Epstein Barr Virus LMP1 and Human papillomavirus
type 16 primary antibodies. Sixty-three percentage (19 out of 30) of the studies group showed positive overexpression as shown
in with a significant association of the expression with cervical cancer with a significant association (p = 0). The co-infection of
the EBV and HPV-16 supports the hypothesis regarding the possible role of the EBV infection to increase the burden of the
cervical squamous carcinogenesis.