EFFECT OF EXPRESSION OF TAFAZZIN (TAZ) ON THE DEVELOPMENT OF CERVICAL CARCINOMA

EFFECT OF EXPRESSION OF TAFAZZIN (TAZ) ON THE DEVELOPMENT
OF CERVICAL CARCINOMA

ABSTRACT : Cervical cancer representsone of the possibly preventable cancer. The study was designed to find the possible
correlation of Tafazzin on the progression of cervical carcinoma. Two groups of paraffinized blocks were included. The study
group of 30 cervical tumors as well as 15 biopsies of healthy cervical tissues. After sectioning on a positive charge,
immunohistochemical application (IHC) was performed to detect Tafazzin expression. Nighnty percentage (27 out of 30) of the
studies group showed positive overexpression as shown in with a significant association of the expression with cervical cancer
with a significant association. There is a possible role of TAZ in hastening the development of cervical cancer through different
mechanisms. Further studies with large samples are recommended.