Biomarker Significance of Serum CXCL٨, CXCL١٠ and CXCL١٦ in Breast Tumors of Iraqi Patients
Aseel F. Khalaf – Munawar A. Al-naqqash – Nada A.S. Alwan – Ali H. Ad’hiah
Abstract:
The biomarker significance of three chemokines (CXCL٨, CXCL١٠ and CXCL١٦) was evaluated in sera of ٤٥ breast cancer (BC) and ٢٨ benign breast lesion (BBL) patients, as well as ٢٠ control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth
factor receptor-٢ (HER-٢) receptors were considered in this evaluation. The results demonstrated thatCXCL٨, CXCL١٠ and CXCL١٦ showed a significant increased median in BC and BBL patients compared tocontrol (CXCL٨: ٤٧.٣ and ٢٥.٧ vs. ١٥.٠; CXCL١٠: ٣٧.٦ and ٣٠.٧ vs. ١٣.١; CXCL١٦; ٢٧.٩ and ٢٥.٢ vs. ١٩.٢ pg/ml, respectively). The increased levels of CXCL٨ and CXCL١٦ were more pronounced in triple-negative and HER-٢ positive patients, respectively. Binary logistic regression analysis revealed that CXCL٨ was a
significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiveroperating characteristic analysis also revealed that CXCL٨ recorded an area under curve of ٠.٩٩٨ in BC patients. In conclusion, CXCL٨ is a potential biomarker for BC, especially when ER, PgR and HER-٢ expression is considered. In this context, the predictive significance of CXCL٨ in influencing BCprogression is suggested in triple-negative patients.