{"id":16140,"date":"2019-01-09T12:11:25","date_gmt":"2019-01-09T09:11:25","guid":{"rendered":"http:\/\/bccru.uobaghdad.edu.iq\/?p=16140"},"modified":"2019-01-09T12:13:01","modified_gmt":"2019-01-09T09:13:01","slug":"clinical-pathology-and-immuno-histochemistry-of-mammary-tumors-from-military-pet-dogs-in-iraq","status":"publish","type":"post","link":"https:\/\/bccru.uobaghdad.edu.iq\/?p=16140","title":{"rendered":"Clinical pathology and immuno-histochemistry of mammary tumors from military\/pet dogs in Iraq"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_wp_text]<\/p>\n<p style=\"text-align: center\"><strong>\u0645.\u0645. \u0647\u062f\u0649 \u0627\u0644\u0639\u0628\u0648\u062f\u064a \u0648 \u062f. \u0627\u0646\u0639\u0627\u0645 \u0644\u0641\u062a\u0629<\/strong><\/p>\n<p style=\"text-align: center\"><strong><a href=\"http:\/\/onljvetres.com\/dogtumoriraqabs2018.htm\">Online Journal of Veterinary Research<\/a>, Vol. (22)7, 2018<\/strong><\/p>\n<p>[\/vc_wp_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_wp_text]<\/p>\n<p style=\"font-weight: 400;text-align: left\"><strong>Abstract<\/strong>: Authors previously reported ~25% mammary tumors in dogs in Iraq which they partly attribute to carcinogenic war materials such as TNT. In our study, 10 virgin un-spayed military\/pet bitches aged 5-15 years presented April 2016 to December 2017 with\u00a0abnormal masses in the abdomen with painful\u00a0oedema, swelling, anorexia, weight loss, weakness and mild fever. Examination of regional lymph nodes and thoracic radiography confirmed metastasis.\u00a0Tumors were excised and determined to be mostly canine adenocarcinomas (CMT), involving multiple glands, solid in texture, 5-15 cm in size, located mostly in the inguinal mammary glands at stage\u00a0T3: &gt;5 cm. Microscopy\u00a0confirmed presence of adenocarcinoma in 8 dogs and solid carcinoma in 2 with half of tumors being grade III. Tumors had pleomorphic hyperchromatic cell nuclei in stroma, epithelial cells of ducts with\u00a0squamous metaplasia, fibrosis and infiltrates of inflammatory cells in interstitial mammary tissue. In papillary carcinomas, we also found papillary projections into glandular acini, with proliferation of epithelial cells.\u00a0Gross lesions appeared as multiple ulcerated cranial abdominal masses with congestion and bloody edema. Expression\u00a0of oestrogen (ER) and progesterone receptors (PR), and proliferation marker (Ki-67) were determined by\u00a0immunohistochemistry. Samples were negative for ER and PR except for one PR sample which stained strongly. This dog had a small low grade tumor (3 cm) grade. Tumors from 7 dogs were strongly positive to Ki-67 localized in the nuclei of cells, but 3 tumors stained negative or weak. Follow\u00a0up for 18 months, included health status, recurrence or metastasis. Only\u00a03 dogs survived with others dying by 12 months.<\/p>\n<p style=\"font-weight: 400;text-align: left\"><strong>Keywords<\/strong>: Mammary tumor, dogs, histology, immunohistochemistry, ER, PR, Ki-67<\/p>\n<p>[\/vc_wp_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_wp_text] \u0645.\u0645. \u0647\u062f\u0649 \u0627\u0644\u0639\u0628\u0648\u062f\u064a \u0648 \u062f. \u0627\u0646\u0639\u0627\u0645 \u0644\u0641\u062a\u0629 Online Journal of Veterinary Research, Vol. (22)7, 2018 [\/vc_wp_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_wp_text] Abstract: &#8230; <a class=\"cz_readmore\" href=\"https:\/\/bccru.uobaghdad.edu.iq\/?p=16140\"><i class=\"fa fa-angle-left\" aria-hidden=\"true\"><\/i><span>\u0627\u0644\u0645\u0632\u064a\u062f<\/span><\/a><\/p>\n","protected":false},"author":43,"featured_media":16141,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[10],"tags":[],"class_list":["post-16140","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-10"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Clinical pathology and immuno-histochemistry of mammary tumors from military\/pet dogs in Iraq | \u0627\u0644\u0645\u0631\u0643\u0632 \u0627\u0644\u0648\u0637\u0646\u064a \u0627\u0644\u0631\u064a\u0627\u062f\u064a \u0644\u0628\u062d\u0648\u062b \u0627\u0644\u0633\u0631\u0637\u0627\u0646<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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