{"id":16128,"date":"2019-01-09T08:44:36","date_gmt":"2019-01-09T05:44:36","guid":{"rendered":"http:\/\/bccru.uobaghdad.edu.iq\/?p=16128"},"modified":"2019-01-09T10:57:26","modified_gmt":"2019-01-09T07:57:26","slug":"nuclear-targeting-of-latent-membrane-protein-1-of-epstein-barr-virus-in-tissues-from-patients-with-pancreatic-carcinoma","status":"publish","type":"post","link":"https:\/\/bccru.uobaghdad.edu.iq\/?p=16128","title":{"rendered":"NUCLEAR TARGETING OF LATENT MEMBRANE PROTEIN 1 OF EPSTEIN BARR VIRUS IN TISSUES FROM PATIENTS WITH PANCREATIC CARCINOMA"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_wp_text]<\/p>\n<p style=\"text-align: center\"><strong>\u0645. \u0628\u0627\u0633\u0645 \u0645\u062d\u0645\u062f\u060c \u0627.\u0645.\u062f. \u0643\u0641\u0627\u062d \u0639\u0628\u062f \u0627\u0644\u063a\u0641\u0648\u0631\u060c \u0623.\u062f. \u0633\u0639\u062f \u0645\u062d\u0645\u062f \u0648 \u062e\u0644\u064a\u0644 \u0627\u0633\u0645\u0627\u0639\u064a\u0644<\/strong><\/p>\n<p style=\"text-align: center\"><strong><a href=\"https:\/\/bccru.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/41\/2019\/01\/NUCLEAR-TARGETING-OF-LATENT-MEMBRANE-PROTEIN-1-OF-EPSTEIN-BARR-VIRUS-IN-TISSUES-FROM-PATIENTS-WITH-PANCREATIC-CARCINOMA.pdf\">Biochemical and Cellular Archives<\/a>, Vol.18, Supplement 1, pp. 1293-1297, 2018<\/strong><\/p>\n<p>[\/vc_wp_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_wp_text]<\/p>\n<p style=\"text-align: left\"><strong>ABSTRACT<\/strong>:<strong> Many studies have implicated EBV in the pathogenesis as well as carcinogenesis of a relevant range of malignant squamous cell carcinomas.\u00a0<\/strong><strong>The present retrospective study was designed to: (1) investigate the frequency of EBV infections associated with the pancreatic carcinoma, (2) explore the impact this virus on the expressed histopathological grades and the stages of those cancers; and (3) screen the <\/strong>expressedimmunohistochemical<strong>&#8211; EBV Latent Membrane Protein-1 reactions, as referred to signal scores and intensities of these reactions in the tested specimens. The current retrospective study enrolled a number of 29 paraffinized pancreatic tissues from the archives of the period 2011- 2017 of the major hospitals and many private histopathological laboratories in Baghdad. The research included 19 pancreatic\u00a0<\/strong><strong>carcinomatous tissues as well as 10 biopsies from <\/strong>an apparently normal pancreatic tissues<strong>. Each 4 mm \u2013 thick sections of the requested tissue block was stuck on a positive charged slide to be used for an immunohistochemical (IHC) technique for detecting EBV Latent Membrane Protein 1 using monoclonal primary antibodies against them. Histopathological examination revealed that well, moderate and poor grades of pancreatic carcinomas constituted 21%, 63% and 16%, respectively. The EBV- LMP1 was detected in 42% (8 out of 19) of pancreatic cancerous tissues. Seven out of eight\u00a0<\/strong><strong>tissues with positive EBV-LMP1 reactions have <\/strong>moderate<strong> differentiated grade, while only one tissue (1 out of 8) have <\/strong>well-differentiated<strong> grade and no expression of poor differentiation. It could possibly point that EBV infections in pancreatic carcinomas could have an initiating and\/or cofactor roles, in collaboration with other important oncogenic factors or agents in the pancreatic carcinogenesis which could <\/strong>happened<strong> as an early- event <\/strong>along<strong> other molecular attacks in this process.<\/strong><br \/>\n<strong>Key <\/strong>words :<strong> Epstein Bar Virus, Latent Membrane Protein 1, immunohistochemistry, pancreatic carcinoma.<\/strong><\/p>\n<p>[\/vc_wp_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_wp_text] \u0645. \u0628\u0627\u0633\u0645 \u0645\u062d\u0645\u062f\u060c \u0627.\u0645.\u062f. \u0643\u0641\u0627\u062d \u0639\u0628\u062f \u0627\u0644\u063a\u0641\u0648\u0631\u060c \u0623.\u062f. \u0633\u0639\u062f \u0645\u062d\u0645\u062f \u0648 \u062e\u0644\u064a\u0644 \u0627\u0633\u0645\u0627\u0639\u064a\u0644 Biochemical and Cellular Archives, &#8230; <a class=\"cz_readmore\" href=\"https:\/\/bccru.uobaghdad.edu.iq\/?p=16128\"><i class=\"fa fa-angle-left\" aria-hidden=\"true\"><\/i><span>\u0627\u0644\u0645\u0632\u064a\u062f<\/span><\/a><\/p>\n","protected":false},"author":43,"featured_media":16125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[10],"tags":[],"class_list":["post-16128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-10"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NUCLEAR TARGETING OF LATENT MEMBRANE PROTEIN 1 OF EPSTEIN BARR VIRUS IN TISSUES FROM PATIENTS WITH PANCREATIC CARCINOMA | \u0627\u0644\u0645\u0631\u0643\u0632 \u0627\u0644\u0648\u0637\u0646\u064a \u0627\u0644\u0631\u064a\u0627\u062f\u064a \u0644\u0628\u062d\u0648\u062b \u0627\u0644\u0633\u0631\u0637\u0627\u0646<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bccru.uobaghdad.edu.iq\/?p=16128\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NUCLEAR TARGETING OF LATENT MEMBRANE PROTEIN 1 OF EPSTEIN BARR VIRUS IN TISSUES FROM PATIENTS WITH PANCREATIC CARCINOMA | \u0627\u0644\u0645\u0631\u0643\u0632 \u0627\u0644\u0648\u0637\u0646\u064a \u0627\u0644\u0631\u064a\u0627\u062f\u064a \u0644\u0628\u062d\u0648\u062b \u0627\u0644\u0633\u0631\u0637\u0627\u0646\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_wp_text] \u0645. \u0628\u0627\u0633\u0645 \u0645\u062d\u0645\u062f\u060c 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